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In this article, we will explore some of the various theories that are currently in circulation, which outline the cause as: Excessive production of porphyrin by skin bacteria stimulated by B12 A cobalt allergy Relative deficiency of vitamin B12 cofactors A detoxification reaction Vitamin B12 Acne The Work of Skin Bacteria

It won't necessarily act like caffeine, but if you're sensitive to supplements or have trouble winding down, it may disrupt your sleep cycle

The NIH professional fact sheet is a reliable reference

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Abud Bakri In addition to, it's like if they come see me in clinic, that might be a place where we can have that discussion